Nootropics are supplements that claim to enhance cognitive function. They come in the form of pills, powders and liquids with a variety of different ingredients like caffeine, DHA omega-3 fatty acids or GABA. Where do you start? And how do you know what dosage is right for your brain? We answer all these questions and more!
Nootropics are drugs that have been designed to improve cognitive function. The “nootropic definition” is a drug or medication with nootropic properties. It is often used as a synonym for smart drugs. Nootropics can be purchased online and in some cases, they can be found in local stores.
This Semax review will tell you all there is to know about this incredible nootropic peptide and cognitive enhancer.
What Is Semax and How Does It Work?
The N-acetyl Semax or Semax peptide is a truncated version of the hormone Adrenocorticotropic Hormone, or ACTH.
Only four of the 39 amino acids discovered in the ACTH peptide were used in the creation of Semax, a synthetic peptide medication.
Aside from reducing stress, the medicine improved a person’s memory, anxiety, and cognition. It also assists in the treatment of people suffering from visual neuropathy. The investigation on patients revealed a considerable increase in the formation of cells that transport neurotransmitters, boosting the drug’s action while within the body.
It typically enhances memory and attention as a medication. Other advantages include less mental stress, more cells transporting neurons for various brain systems, and better movement-related symptoms.
|Name||Acetate of Semax|
|Effects||Increases BDNF levels, which enhances attention and memory while also preventing or reducing nerve and brain damage.|
|Potential Negative Consequences||Hair loss|
|Half-Life||Approximately 2 to 10 hours|
|Typical Dosage||50-300 mcg per day|
|Guaranteed money back||30 days|
|Vendor of the Year||Click Here ›|
To figure out which amino acids were responsible for the development of brain function and brain-growth effects, the researchers employed a mix of trial and error and specific analytic tools.
They discovered the shortest functional sequence in the 39-amino-acid hormone, which was the initial step in the peptide medication Semax’s development.
Which Version Is the Most Effective?
Semax products come in a variety of forms:
the first version
Although the unaltered peptide is seven amino acids long, simple to produce, and inexpensive to get, it does not persist as long in the body as we would want.
Improves memory and attentiveness.
Prevents or lessens the effects of nerve and brain damage.
Semax N-Acetyl (NAS)
N-Acetyl Semax has the biggest impact on the brain in terms of stimulation and the quintessential features of it, which are energy, mental stamina, and motivation.
Amidate of N-Acetyl Semax (NASA)
The best variant is N-Acetyl-Semax Amidate, which is possibly because it is the most changed (except Adamax).
Adamax is a new form of Semax that has THREE distinct groups to help with absorption and half-life.
The adamantane group is a huge, chunky, lipophilic diamondoid of the simplest sort that resists enzyme breakdown, allowing it to stay in the body for longer.
Temperature-induced breakdown has no opportunity of being buffered by amidation groups.
Because of its potency and rapid onset, the doses are much lower than with traditional Semax.
The normal Semax dosage range is 50-300 mcg.
Effects and Advantages
Semax has a broad spectrum of effects on the human brain and various linked disorders, according to human experiments and stories. Motivation and mood are the two most often mentioned advantages.
This peptide is unusual in that it is both a robust neurotrophin releaser and a positive monoamine modulator, as well as a modest oxidative stress preventer (even when considering the finest of nootropics that aren’t well known). It has a variety of benefits, including the treatment of individuals with optic nerve damage and enhanced neurotransmitter synthesis, that aren’t reproduced by many other synthetic nootropics.
Semax encourages activity-dependent AMPA trafficking by increasing dopamine and serotoninergic systems in the brain, which implies that circuits that are heavily used have cognitive precedence.
We can observe how the levels of neurotrophins, BDNF, and NGF have changed over time.
For a 65 kg person, the Semax dose was equal to 515 mcg. As you can see, there is a big spike in NGF in the retina after three hours, as well as minor rises in the hippocampus and frontal brain.
Semax is known to quickly induce BDNF, which might explain why the first time point begins with levels almost twice those of the control group.
It’s vital to remember that human handling provides a rich experience for rats and may raise neurotrophin levels on its own.
The brainstem is number one, followed by the cerebellum, the frontal cortex, the hippocampus, and the retina.
This graph contrasts the expression of NGF in rats given Semax intranasally vs animals given water. This contradicts earlier research that demonstrate a surge in NGF levels in the frontal cortex of the brain… but low levels in the retina.
The brainstem is number one, followed by the cerebellum, the frontal cortex, the hippocampus, and the retina.
This graph shows the difference in BDNF expression between rats given water intranasally and rats administered Semax intranasally.
The placebo rats were constantly terrified of being grabbed up by a giant hand and put a needle into a very intimate location, which may produce neurotrophins. This might explain the decline in prefrontal trophic levels.
Low prefrontal BDNF levels also seem to be beneficial for specific ages and activities.
Hippocampal BDNF aids in the improvement of a wide range of cognitive abilities.
Effective cognitive training enhances activity of the medial prefrontal cortex, which is situated in the DMN frontal subcomponent, according to a meta-analysis of data obtained in the brains of young volunteers.
“Regulation of brain states, change of cortical tone, desires, and emotional life” are the key functions of the medial cortex, which is strongly linked to the limbic system and reticular formation.
These tissue and extracellular (dopamine) concentrations were unaffected by Semax alone (0.15 and 0.6 mg/kg, i.p). (data are not shown).
Semax has no effect on dopamine levels. However, the drug’s activities cause a large increase in serotonin.
More serotonin may explain behavioral changes such as a more stress-resistant mood and increased energy levels, making it useful for illnesses such as chronic tiredness. The arrow denotes the administration point.
The higher the Semax dosage, the lesser the rise in serotonin turnover.
This is why some individuals say that Semax may increase BDNF levels by 800%.
In actuality, these neurons are from a postnatal era that is far far from that of a fully developed adult brain. Neurotrophins and ligands in general cause neurons to respond.
Also, this isn’t the protein content. To be accepted as properly indicating the quantity of protein generated, this amount of mRNA must be proved highly linked in glial primary cultures throughout postnatal days 1 to 2.
Dosage & Directions for Use
The dosages employed in action in rat brain and human research are quite variable.
It is 500 mcg in humans for the treatment of ischemic stroke and brain damage, according to a clinical trial and electrophysiological investigation.
It has an undeniably wide therapeutic window/dosage range.
The dose of Semax is determined by its form.
Between 100 to 900 mcg of the acetyl form is typically utilized.
Between 200 and 900 mcg of acetyl-amidate (also known as NASA) is often utilized.
Between 50 mcg and 3 mg is utilized in the original form.
Commercial vials of the original, unaltered form contain 50 mcg drops, and some people detect effects after only one drop.
Who knows how that may happen.
Looking back on my Semax experience, I’ve utilized NASA a lot, and I’ve seen that less is more.
Some people claim to be losing their hair. This is assumed to be due to BDNF speeding up the development of hair follicles.
If you have a persistent nervous system issue, it’s possible that Semax will make it worse.
Semax had negative side effects in one person with bipolar disorder.
Although side effects are uncommon, the mechanism of action of Semax is yet unknown.
What’s the Difference Between Semax and Selank?
Semax and Selank are almost indistinguishable.
Selank is a peptide that is similar to tuftsin, an immune system peptide that may boost several types of immune system-mediated immunity against bacteria, viruses, and cancers.
The inclusion of PGP was subsequently supplied to Tuftsin. The rest of the peptide’s activities on its target receptor are consistently continued by this neurotrophic and neuroprotective antioxidant trimer.
PGP is also included in Semax, and it has some interesting neurotrophic activity-increasing qualities.
Semax changed gene expression involved in cell proliferation and migration in the context of experimental localized ischemia. It protects against hemispheric ischemic stroke as well as transient ischemic attack. In the rat brain, it has also been shown to influence the expression of genes relevant to the immunological and vascular systems.
0.15 percent SELANK®
Check the price
Get an 8% discount with the code CN+wholisticresearch 8off!
- The original Selank from Russia was 0.15 percent.
Bottom line: Selank is more anxiolytic and stress-relieving, but Semax, in addition to its analgesic properties, is more energizing and motivating. Selank may be a superior option for the treatment or decrease of anxiety symptoms, stress, strokes, and depressive problems.
Where Can I Purchase Semax?
Semax is available in three distinct forms.
- From a research facility. It’s difficult to accomplish unless you’re well-versed in peptides, have impeccable business etiquette, and own/appear to run a firm. Larger amounts must be purchased, but the per-milligram pricing are the best.
- It comes from a middleman. This is an example of an internet store. After Ceretropic Semax is no longer accessible, this is most likely the best option.
- Russia! Mother Russia sells a variety of marketed Semax strengths that are manufactured in their facilities and dissolved in water. It isn’t always inexpensive, and it may deteriorate while in transportation.
Most Commonly Asked Questions (FAQ)
Answers to your most urgent questions:
What Is The Best Way To Take Semax Nootropic?
Semax therapy increases forebrain functions by boosting selective attention at the time of information receipt, memory consolidation, anxiety and tension reduction, learning capacity enhancement, and total brain function enhancement.
For overall neurological and emotional well-being. Semax has even been offered as a therapy option for mental stress that is generally beneficial!
It may help protect neurons from glutamate excitotoxicity.
It may aid with depression, mental stress, and ADHD by amplifying the effects of dopaminergic stimulants.
It may also be used to treat people with optic nerve illness when combined with other anti-inflammatory medications.
Semax has a very low risk of side effects.
What Is Semax Nasal Spray and How Does It Work?
Semax has been administered intravenously, subcutaneously, and sublingually. Each of these options has its own set of features, advantages, and disadvantages.
The nose has been shown to be an excellent delivery method for reclaiming neurological health in a variety of brain health disorders, even delivering drugs more effectively than intravenous administration.
Drugs may be delivered to the back and front of the brain by retrograde axonal transport and vagus nerve transport, reducing the risk of the material reaching the patient’s other organs.
Semax reviews for intranasal use, on the other hand, are quite mixed. Some patients claim more powerful results, while others experience the reverse. Other administration techniques may be preferable if intranasal Semax spray isn’t working.
Despite all of the clinical studies on the efficacy of intranasal therapy in patients, I have never observed any benefit from it. Selank, on the other hand, performs better intranasally for me than injections!
Absorption processes change depending on the peptide.
The point here is that you are unique, but don’t say Semax doesn’t work until you’ve tried at least two therapy administration techniques!
How long is it going to last?
‘Semax,’ a synthetic analog of ACTH 4-7 (not ACTH 4-10) Met-Glu-His-Phe-Pro-Gly-Pro, was created to prolong some of the effects.
Users of Semax report a wide range of duration and half-life. Intranasal delivery is a variable to consider since it lasts for a shorter amount of time than injections. Approximately 2 to 10 hours.
When Should You Take This Nootropic?
It is meant to be used on a daily basis for clinical and electrophysiological research. Semax from Russia, which has a lower concentration (0.1 percent), is indicated for daily usage for healthy cognitive improvement (such as boosting learning and memory, mood, and brain function in general).
How Quickly Does Tolerance Develop?
With Semax, there’s a built-in reverse tolerance. The longer you take it, the less you will need.
Is It Effective in the Treatment of ADHD?
Yes, Semax may assist with ADHD symptoms.
Does It Have an Impact on Cortisol Levels?
Your cortisol levels may be affected by adrenocorticotropic hormone (ACTH).
Is It Legal In The United States?
Yes, it is lawful in the United States and has FDA approval.
Is it permissible in Australia?
Yes, it is permissible in Australia.
Watch This Video-
The “nootropic drugs” is a type of medication that helps to improve cognitive function. The effects, dosage and where to buy nootropics are discussed in this blog post.
- nootropics side effects
- nootropics examples
- do nootropics work
- nootropic supplements
- nootropics for adhd