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One of the most dreaded consequences of aging is memory loss, and PRL-8-53 seems to be the solution to this problem.
Would you think that PRL-8-53 improved the memory of its participants by more than 200 percent in a human study?
In that regard, this nootropic seems to be promising. Is it, however, more than a cognitive enhancer?
In this PRL-8-53 review, we’ll discover out.
What exactly is PRL-8-53?
PRL-8-53 [R] is a benzoic acid and phenylethylamine-derived synthetic nootropic. Benzoic acid may be found in a variety of foods, including dairy products, fruits, and plants.
Methyl 3-2-benzyl methyl amino ethyl benzoate is the drug name for PRL-8-53. It’s a potential supplement created by Dr. Nikolaus Hansl at Creighton University in 1972.
Dr. Hansl, PRL-8-147, also developed a stronger version of PRL-8-53, according to rumors and papers.
In 1978, Dr. Hansl performed a human trial in which participants received a single dosage that quadrupled their memory.
As a result of this finding, PRL-8-53 has become one of the most talked-about nootropics on the market.
It’s even been dubbed a “strong supplement” by neurohackers, since it improves memory creation, retention, and recall while also boosting general cognitive performance.
Methyl 3 2 benzyl, as a brain supplement, causes alterations in one’s capacity to think and process information. Its chemical composition protects brain cells from harm and helps to avoid neurological disorders.
The mental faculties of attentiveness, concentration, and intellect operate at their best when cognitive function is improved.
What Is the Process?
PRL-8-53, or 3-2-benzyl methyl amino ethyl benzoate, controls neurotransmitters. It increases dopamine, regulates serotonin, and improves acetylcholine function, according to Dr. Hansl.
Acetylcholine is a neurotransmitter that helps you remember things. Increased dopamine levels, on the one hand, make you more focused, active, and driven.
Serotonin is a neurotransmitter that helps with sadness, anxiety, and sleeping problems. To avoid such unproductive situations, PRL 8 53 (53*8) suppresses serotonin synthesis.
The participants in the lone study were anticipated to acquire impulsive aggressive disorders as a result of dopamine and serotonin activities. Such adverse effects, on the other hand, were not common among them.
Effects and Advantages
Nootropics are used to enhance cognition. Supplementing with PRL-8-53 has been shown to enhance mental skills in a short amount of time, according to studies.
Because there have been few research on this supplement, its effects and advantages have yet to be formally published for representation. This assertion, however, is backed up by anecdotal evidence.
Its capacity to enhance mental ability and cognitive function has been attested to by users. PRL-8-main 53’s advantages are these two.
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Let’s talk about it a bit more.
Improving long-term memory
Evidence indicated that participants were given a dose of 5 mg of PRL-8-53 2 hours before a memory test in the sole human clinical study.
They were given recordings with 12 words in different sequences to listen to. They were then asked to remember the words immediately after completing the exam.
Two hours and 96 hours following the test, participants were asked to remember the words once again.
The quick recall revealed no advantages from using PRL-8-53 in these three cases. However, the most recent test revealed an 80 percent improvement in the outcome.
Visual memory has improved.
Dr. Hansl’s unpublished study reveals the results of a test in which participants were asked to remember geometric designs by sketching them on a sheet of paper.
This test provides strong statistical evidence that the PRL-8-53 supplement improves visual memory performance.
Fluency in the English language
When participants were asked to construct words using dots and letters, another test outcome that has yet to be discovered. PRL-8-53 users had better outcomes, which adds to the drug’s potential for improving verbal fluency.
Other possible advantages of the medication may be derived from different chemical processes in the brain.
The following are some of the findings from animal clinical studies. As topics, they are also thought to take place in the human brain.
Dopamine production is increased.
As we become older, our bodies produce less dopamine. This process has a big influence on our thinking. The chemical inhibits dopamine synthesis, which helps to prevent age-related memory loss and cognitive decline.
Formation of long-term memory
When tested on animals, the medication enhanced peripheral and central noradrenaline responses. If the same effect can be seen in people, it is quite likely that long-term memory storage may be increased.
Enhances the cholinergic system
The medication boosts the brain’s cholinergic reaction. It means it can help the chemical system involved in memory creation, storage, and retrieval.
Dosage
Clinical studies to determine the appropriate dosage of PRL-8-53 have been limited.
What is easily accessible in sufficient quantities to demonstrate its well-known advantages among users? The published research suggests that you take 5 mg. The participants gradually increased their dose to 10-20 mg each day, depending on the results.
The patent information includes an optimum PRL-8-53 dose. The dose to body weight proportion is. 1-4mg/kg. This ratio is divisive because it allows for a broad range of dose variation.
PRL-8-53 Directions for Use
There is no indication of risk when the medication is used at its maximum dosage. However, it was shown to be deadly in animal testing.
The powder supplement may be taken in a variety of ways, but Dr. Hansl’s team advises taking it by mouth.
When purchasing PRL-8-53, powder jars containing 1 to 5 grams of PRL-8-53 are commonly available. It may be ingested, mixed into a drink, or taken as capsules.
Consequences
Based on the short clinical study, PRL-8-53 is a well-tolerated nootropic with no severe adverse effects.
It is anticipated to have comparable adverse effects to other nootropics if it does have any.
While taking the medication, users may feel a slight headache. Apart than that, nothing more has been reported.
High dosages were shown to impair motor function in an animal investigation. This needs to be investigated further in people.
To prevent side effects, start with modest dosages and gradually increase them depending on how your body reacts.
On Reddit, people share their experiences.
Here are some Reddit experiences with PRL-8-53.
In the words of inmy325xy:
“I began with modest dosages and gradually increased the size of my doses. I think 10mg is a wonderful daily dosage, and 15mg didn’t appear to be a significant improvement over 10. However, for my Neuroscience exam on Friday, I opted to try 20mg and was blown away by the improvement in memory I had.”
Baliflipper claims that:
“With PRL, I’ve seen an improvement in verbal fluency. It’s an excellent study aid when combined with coffee. However, as previously said, it must be used in conjunction with studying and while taking the test to ensure memory.”
wave78 claims that:
“I remembered approximately 300 questions for a test in about 3 hours with PRL, Semax, and caffeine. That combination was fantastic for memory. By the way, I have a terrible memory. I’m not a child. I, too, drank heavily throughout the most of my life. If you know me, you know that recollection is not one of my strong suits. I keep it in reserve for such times.”
In this review, you can learn more about the study and how to purchase PRL.
Stacks
Nootropics have a synergistic effect. Each one has its own set of advantages, and correctly stacking them causes the body to respond positively.
Despite the lack of study and knowledge of PRL-8-advantages 53’s and mechanisms, we can still trust that the stacked supplements provide the best results when taken together.
Why Use PRL-8-53 in Combination with Other Supplements?
A “stack” is a combination of two or more nootropics taken at the same time. Stacking chemicals in cognitive enhancers is a popular technique since it may increase their benefits.
A stack may work well with the following, according to anecdotal evidence:
B12 (cobalamin)
Alpha GPC
Memantine
Sunifiram
Sex
Phenylpiracetam
The supplements listed have only been tried by individuals and are not based on research. There is no proof that these drugs are safe to combine with PRL-8-53.
Where can I get PRL-8-53 Capsules and Powder?
Experimental medicines should only be purchased from reputable sources. It is unregulated, and any seller may claim that their goods are genuine.
Lab-tested supplements are offered by reputable nootropic suppliers like Science.bio, so consumers can be confident of their purity and identification. Customers are also guaranteed of proper handling techniques for shipment, so they won’t have to worry if they purchase from afar.
PRL-8-53 powder comes in half-gram, one-gram, and five-gram jars.
Most Commonly Asked Questions (FAQ)
Although there is little study on this substance, we can nevertheless address some fundamental queries that may have occurred to you.
What is PRL-8-Half-Life? 53’s
Users have reported feeling effects 30 minutes after taking the medication.
It lasts for 2-4 hours in the body. Some people recommend taking it 30 minutes before your planned activity.
What is the cost of PRL-8-53?
PRL-8-53 solution is available for $29.99 on Science.bio. You may get it for as little as $20.99 if you purchase in quantity.
A 500 mg jar of powdered form is available. It costs $14.99 a jar and just $10.49 per jar when purchased in bulk.
Conclusion
PRL-8-53 was developed in the lab with the goal of improving memory and cognitive function. Despite the lack of studies on its potential advantages, it has gained a large number of advocates due to its cognitive effects.
More proof may be required to establish its value in the nootropic community. However, it will continue to be regarded as one of the finest cognitive enhancer supplements as long as it is unregulated and has no known harm when used long-term.
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- Shipping is available the same day.
- Testing by a third party
- Money-back guarantee for 30 days
Sildenafil is a drug that is used to treat high blood pressure and erectile dysfunction. It can be taken in different dosages, with the most common being 100mg. Reference: sildenafil dose for high blood pressure.
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